Entamoeba
Life
> Eukaryotes > Amoebozoa
> Entamoebida
Single-celled organisms that fall within the amoeba
functional group and which are parasites or commensals of all major groups of
vertebrates as well as a few invertebrates. The life cycle typically
consists of an infective cyst stage and a multiplying trophozoite stage.
Worldwide, Entamoeba histolitica, which causes amoebic dysentery and
amoebic liver abscess, is the third most death-causing parasitic disease after
malaria
and schistosomiasis, with 50 000 to 100 000 deaths caused annually.
Whole genome sequencing of Entamoeba histolitica as
well as other Entamoeba species is taking place (see Links).
Genetic methods are becoming increasingly important in
helping to distinguish the different species of Entamoeba. This is
important as some species cause disease (e.g. Entamoeba histolitica)
whereas others don't, and one needs to know the difference in order to assess
treatment action. Up to six species of Entamoeba have been found in
humans.
Some species likely to be encountered in southern Africa
Entamoeba coli
A commensal species that does not cause disease, found in the intestinal
tract of humans and other animals. |
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Entamoeba dispar
Entamoeba histolitica in the old sense, has been found to be made up
of two species: true Entamoeba histolitica (previously known as
'pathogenic E. histolytica') and Entamoeba dispar (previously known
as 'non-pathogenic E. histolytica'). As the terms suggest, Entamoeba
dispar does not cause disease, but it is commonly found in humans and
other animals, in fact more commonly so than Entamoeba histolitica. |
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Entamoeba gingivalis
Lives in the mouth (teeth, gums, tonsils) of humans and other animals (e.g.
primates, dogs and cats) where it eats bacteria and blood cells
(leukocytes and erythrocytes). Note that the gum disease called gingivitis,
which causes inflamation of the gums, is caused by bacteria rather than
Entamoeba gingivalis. However, the presence of the latter is normally
associated with poor oral hygiene which in turn is associated with heavy
plaque (bacterial biofilms) and gingivitis. |
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Entamoeba histolitica
The cause of amoebic dysentery and amoebic liver abscess in humans and also
infects other animals such as dogs, pigs and cattle. Transmission is through
the consumption of cysts in faecal-infected water or food |
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Entoamoeba invadens
A intestinal parasite of reptiles such as snakes and lizards that causes
disease similar to that caused by Entamoeba histolitica. Also found
in turtles but does not seem to cause disease in these animals. |
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Entamoeba moshkovskii
This species has become secondarily free-living and is commonly found
worldwide in anoxic sediments such as are found in sewage pans and the
bottoms of muddy rivers. However, is can also be found in clean river
sediments and in brackish coastal pools. It is rarely found in humans and in
such cases has not caused sickness. |
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Entamoeba terrapinae
A commensal species found in turtles. |
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